Cheesy Loaded Meatloaf Casserole is the ultimate comfort food, combining the flavors of classic meatloaf with the indulgence of melted cheese and savory toppings. Ground beef, Italian sausage, breadcrumbs, and a gooey cheese layer are topped with a tangy ketchup glaze, making it an irresistible dish. Whether for a weeknight dinner or a special occasion, this casserole will be the star of the meal.
1 pound ground beef
½ pound Italian sausage
1 medium onion (diced)
1 cup breadcrumbs
½ cup milk
2 large eggs
1 teaspoon garlic powder
1 teaspoon onion powder
1 teaspoon dried oregano
1 teaspoon dried basil
½ teaspoon salt
½ teaspoon black pepper
1 cup shredded cheddar cheese
½ cup shredded mozzarella cheese
½ cup ketchup
2 tablespoons brown sugar
1 tablespoon Worcestershire sauce
Preheat the oven to 375°F (190°C).
Mix the meat: In a large bowl, combine ground beef, Italian sausage, diced onion, breadcrumbs, and milk. Stir in eggs, garlic powder, onion powder, oregano, basil, salt, and pepper. Mix well until fully combined.
Add the cheeses: Gently fold in shredded cheddar and mozzarella cheese.
Form and bake: Transfer the meat mixture into a greased 9x13-inch casserole dish, forming a loaf shape. Bake for 45-55 minutes, or until the meatloaf reaches an internal temperature of 160°F (71°C).
Make the glaze: In a small bowl, combine ketchup, brown sugar, and Worcestershire sauce. Stir until smooth.
Glaze and bake again: After the meatloaf has baked, spread the ketchup mixture over the top and bake for an additional 10 minutes, until the glaze is set.
Rest and serve: Let the casserole rest for 10 minutes before slicing. Serve warm with your favorite sides.
Calories: 450 kcal
Carbohydrates: 15g
Protein: 28g
Fat: 30g
Saturated Fat: 12g
Cholesterol: 80mg
Sodium: 700mg
Potassium: 550mg
Fiber: 2g
Sugar: 9g