Mechanism of Action
SNRI developed as antidepressant
Dose
5, 10, or 15mg daily
Evidence
Cochrane review; 5 RCTs x 1 year
Wt loss vs. placebo 4.3kg (3.6 - 4.9)
ß 4.6% of baseline wt ³
10% wt loss = 15% (4-27)
Adverse Effects
Ý BP & pulse
Reference
Padwal, et al. Cochrane Database Syst Rev. 2004;(3):CD004094