Safety

Become informed about evidence, dosage, safety and side effects of SAMe.

Now that you have learned about SAMe, go to the next section to learn more about 5-HTP.

SAMe is an extremely safe product to use, and safety concerns are generally few. One issue to consider is that it is an expensive ingredient, and in the past independent reviewers have found that products have contained less of the active ingredient than listed on the label. A more recent survey by the same reviewers, however, found this not to be the case. (consumerlab.com).

Also note that:

  • Mania is a theoretical concern in patients with bipolar disease

  • Caution should be used in patients also taking serotonin-specific re-uptake inhibitor (SSRIs)