SAMe

Another supplement that can be helpful for patients with depression is SAMe. This methyl donor may be able to help both the physical and emotional symptoms of depression making it a good choice in patients with many somatic symptoms. Its mild side effect profile also makes it ideal for patients who are hesitant to take anything at all.

SAMe is formed from the amino acid methionine. It is a methyl donor found in every cell of the body, and it helps support the production of neurotransmitters such as serotonin, norepinephrine and dopamine. Patients with worsening depression complicated by pain syndromes may be good candidates to use this supplement. Indeed, SAMe exhibits anti-arthritis properties and has been used in the treatment of fibromyalgia as well as depression. This supplement may also be particularly helpful for patients with a tendency to procrastinate, or by those who generally feel "stuck" and unable to move forward either in their treatment or in their life situation.