There were times in my life when I had absolutely nothing, I was down and out.
Hank's lost his job, that's why he's been down in the dumps lately.
Andy's house burned down and she has no insurance. She really is down on her luck.
Here's a toast to you, Frank! Down the hatch!
I like Ben, he's a nice, sensible, down to earth guy.
Both teams are playing very well, the game can be won by either of them, it'll go down to the wire.