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ข้อมูลขนาดยาในเด็ก
Drug
Pediatric Dose
2-PAM
IM,IV : 20-50 mg/kg/dose repeat in 1-2 hrs if muscle weakness
Acetylcysteine
( 200 mg powder )
Mucolytic ; < 2 y : 200 mg once daily
2-6 y : 200 mg bid , > 6 y : 200 mg tid
Adrenaline
SC : 0.01 ml/kg/dose of 1:1000 solution ; Max 0.5 mg
Albendazole
Strongyloidias/tapeworm : < 2y ;200 mg/day x 3 วัน ; may repeat in 3 wks
>2y ;400 mg/day x 3 วัน ; may repeat in 3 wks
Hookworm/pinworm,roundworm ; <2y ;200 mg/day single dose; may repeat in 3 wks , > 2y ;400 mg/day single dose;
may repeat in 3 wks
Amikacin
IV ,IM : 15-22.5 mg/kg/day divided q 8 hrs
AmmonCarb (เด็ก)
1-3 y : ½ ช้อนชา tid-qid, 3-6 y: 1 ชอนชา tid-qid, 6-12 y: 2 ชอนชา tid-qid
Amoxicillin
PO : 25-50 mg/kg/day in divided q 8 hrs ; Max 60-80 mg/kg/day : acute otitis media
Amoxicillin + Clavulanic acid Neonate - 3 mo : PO 30 mg amox /kg/day divided q 12 hrs
Children < 40 kg : PO 20-40 mg amox /kg/day divided q 8 hrs
Ampicillin
PO : 50-100 mg/kg/day divided q 6 hrs ; Max 2-3 gm/day
IV/IM : 100-200 mg/kg/day divided q 4-6 hrs ; Max 12 g/day
Meningitis : IV/IM : 200-400 mg/kg/day divided q 4-6 hrs
Aspirin
Analgesic , antipyretic : PO 10-15 mg/kg/dose q 4-6 hrs ; Max 4 g/day
Antiinflam. : PO 80-100 mg/kg/day divided q 6-8 hrs ;
Kawasaki disease : PO 80-100 mg/kg/day divided q 6 hrs ; after fever resolves 3-5 mg/kg/day once daily
Astemizole
< 6 y : PO 0.2 mg/kg/day once daily , 6-12 y : PO 5 mg/day once daily
> 12 y : PO 10-30 mg/day once daily
Drug
Pediatric Dose
Benzathine Pen G
IM : 25000 - 50000 unit/kg single dose ; Max 1.2 mu /dose ( RF 25000 - 50000 unit/kg q 3-4 week ; Max 1.2 mu/dose )
Benztropine
( cogentin )
Drug induced Extra. : < 3 y : should be reserved for life-threatening emergencies
> 3 y : PO,IV,IM 0.02-0.05 mg/kg/dose 1-2 times/day
Bisacodyl
< 2 y : suppo 5 mg/day single dose , 2-12 y : suppo 5-10 mg/day single dose ,
PO 0.3 mg/kg/day ( 5-10 mg/day ) as single dose
Brompheniramine
( 2 mg/5 ml )
< 6 y ; PO 0.125 mg/kg/dose q 6 hrs ; Max 6-8 mg/day
6-12 y ; PO 2-4 mg q 6-8 hrs ; Max 12-16 mg/day
Carbocysteine
2-5 y: 62.5-125 mg 4 times/day, 6-12 y: 250 mg 3 times/day
Cefaclor
PO : 20-40 mg/kg/day divided q 8-12 hrs ; Max 2 g/day
Cefazolin
IV,IM : 50-100 mg/kg/day divided q 8 hrs ; Max 6 g/day
Cefdinia
PO: 14 mg/kg/day OD หรือ 7 mg/kg q 12 hrs; Max 600 mg/day
Cefepime
< 12 y : safety and efficacy not been established
มีการทดลองในเด็กอายุ < 15 ป ใหยา IV ขนาด 50 mg/kg/dose q 8 hrs
Cefixime
PO 8 mg/kg/day divided q 12-24 hrs ; Max 400 mg/day
Cefotaxime
< 12 y : IV , IM : 100-200 mg/kg/day divided q 6-8 hrs
( Pneumococcal meningitis = 225-300 mg/kg/day )
> 12 y : IV , IM : 1-2 gm q 6-8 hrs ; Max 12 gm/day
Cefoxitin
IV , IM : 80-100 mg/kg/day divided q 6-8 hrs ( severe infec. 100 -160 mg/kg/day divided q 4-6 hrs ; Max 12 gm/day
Ceftazidime
IV , IM :100-150 mg/kg/day divided q 8 hrs (meningitis:150 mg/kg/day );Max 6 g/day
Ceftriaxone
IV,IM:50-75 mg/kg/day divided q12-24 hrs (meningitis:80-100 mg/kg/day );Max4 g/day
Cefuroxime
IV , IM : 75-150 mg/kg/day divided q 8 hrs ; Max 6 gm/day
( meningitis not recommened ; dose of 200-240 mg/kg/day ; Max 9 gm/day )
Drug
Pediatric Dose
Cephalexin (125mg/5ml)
PO 25-100 mg/kg/day divided q 6 hrs ; Max 4 gm/day
Cetirizine
> 6 y - adult : 5-10 mg/day
Chloral hydrate
( 200 mg/5 ml )
PO 25-50 mg/kg/day divided q 6-8 hrs ; Max 500 mg/dose
Chloramphenicol
PO, IV: 50-75 mg/kg/day divided q 6 hrs; Max 4 gm/day
(meningitis, IV 75-100mg/kg/day)
Chloroquin
250mg:150mgbase
Acute attack : PO 10 mg base/kg ( Max 600 mg base ) stat ; then 5 mg base/kg 6 hour later and then once daily for 2
days
Chlorpheniramine
( 2 mg/5ml)
< 12 y : PO 0.35 mg/kg/day divided q 4-6 hrs ; Max 12 mg/day
> 12 y : PO 4 mg q 4-6 hrs ; Max 24 mg/day
Cimetidine
Infant : PO,IV,IM : 10-20 mg/kg/day divided q 6-12 hrs
Children : PO,IV,IM : 20-40 mg/kg/day divided q 6 hrs
Ciprofloxacin
PO : 20-30 mg/kg/day in 2 divided dose ; Max 1.5 gm/day
IV : 15-20 mg/kg/day divided q 12 hrs ; Max 800 mg/day
( Cystic fibrosis PO : 40 mg/kg/day divided q 12 hrs ; Max 2 gm/day , IV 30 mg/kg/day divided q 8 hrs ; Max 1.2
gm/day
Cisapride
PO 0.15-0.3 mg/kg/dose 3-4 time/day ; Max 10 mg/dose
Clarithromycin
PO : 15 mg/kg/day divided q 12 hrs ; Max 1 gm/day
Clindamycin
PO : 10-30 mg/kg/day divided q 6-8 hrs ; Max 1.8 gm/day
IV,IM : 25-40 mg/kg/day divided q 6-8 hrs ; Max 4.8 gm/day
Cloxacillin
PO : 50-100 mg/kg/day divided q 6 hrs ; Max 4 gm/day
IV : 50-200 mg/kg/day divided q 6 hrs
Drug
Pediatric Dose
Codeine
Antitussive : PO 1-1.5 mg/kg/day divided q 4-6 hrs
Colistin sulfate
PO : 100000-300000 unit /kg/day
Co-trimoxazole
PO ,IV : 6-10 mg TMP/kg/day divided q 12 hrs ( severe : 15-20 mgTMP/kg/day divided q 6-8 hrs ) ( Prophylaxis of
pneumocystis PO ; 5-10 mgTMP/kg/day divided q 12 hrs 3 day/week ; Max 320 mgTMP/day )
Deferoxamine
Acute Fe toxic : IM : 50mg/kg/dose q 6 hrs ; IV 15 mg/kg/hr ; Max 6 gm/day
Chronic Fe overload : IV 15 mg/kg/hr ; Max 12 gm/day
Diclofenac
PO : 2-3 mg/kg/day divided 2-4 time/day
Dicloxacillin
<40 kg PO : 12.5-25 mg/kg/day divided q 6 hrs( Osteomyelitis 50-100 mg/kg/day )
> 40 kg PO : 125-250 mg q 6 hrs ; Max 2 gm/day
Digoxin
1 mo - 2 y : PO 10-15 mcg/kg/day ; IV , IM 7.5-12 mcg/kg/day
2-5 y : PO 7.5-10 mcg/kg/day ; IV , IM 6-9 mcg/kg/day
5-10 y : PO 5-10 mcg/kg/day ; IV , IM 4-8 mcg/kg/day
> 10 y : PO 2.5-5 mcg/kg/day ; IV , IM 2-3 mcg/kg/day
Dimenhydrinate
PO , IV , IM : 5 mg/kg/day in 4 divided dose , Max 300 mg/day
Diphenhydramine
PO , IV , IM : 5 mg/kg/day divided q 6-8 hrs , Max 300 mg/day
Doxycycline
< 8 y : not recommened
> 8 y : PO ,IV : 2-4 mg/kg/day divided q 12-24 hrs , Max 200 mg/day
Dromperidone
PO : 1.25 ml/5kg ; 3 times/day
(1mg/ml)
Erythromycin
PO : Base 30-50 mg/kg/day divided q 6-8 hrs , Max 2 gm/day
PO : Estolate 20-50 mg/kg/day divided q 6-12 hrs , Max 2 gm/day
PO : Stearate 20-40 mg/kg/day divided q 6 hrs , Max 2 gm/day
Ethambutol
PO 15-25 mg/kg/day once daily , Max 2.5 gm/day
Drug
Pediatric Dose
Famotidine
PO,IV : 0.5 mg/kg/dose 8-12 hrs , Max 40 mg/day
Fuconazole
PO 3-12 mg/kg/day once daily ;Max 600 mg/day
Furosemide
PO 1-6 mg/kg/day divided q 6-12 hrs , IM,IV : 1-2 mg/kg/dose q 6-12 hrs
Gentamicin
IV,IM : 2-2.5 mg/kg/dose q 8 hrs
Griseofulvin
Microsize PO : 10-20 mg/kg/day in single or 2 divided dose
Ultramicrosize > 2 y PO : 5-10 mg/kg/day in single or 2 divided dose
Guaifenesin
< 2 y : PO 12 mg/kg/day in 6 divided dose
2-5 y : PO 50-100 mg q 4 hrs ; Max 600 mg/day
6-11 y : PO 100-200 mg q 4 hrs ; Max 1.2 gm/day
> 12 y : PO 200-400 mg q 4 hrs ; Max 2.4 gm/day
HCTZ
PO: 2 mg/kg/day in 2 divided dose
Hydroxyzine
(10mg/5ml)
PO : 2 mg/kg/day divided q 6-8 hrs
Hyoscine -N-butyl bromide
(1 mg/ml )
PO : > 1y ; 5-10 ml 3 times/day
Ibuprofen
Analgesic : PO 4-10 mg/kg/dose q 6-8 hrs
Antipyretic : PO 5-10 mg/kg/dose q 6-8 hrs ; Max 40 mg/kg/day
Juvenile rheumatoid arthritis : PO 30-50 mg/kg/day in 4 divided dose ; Max 2.4 g/day
Imipenem and cilastatin
IV infusion , IM : 40-60 mg/kg/day divided q 6 hrs ; Max 4 gm/day
Indomethacin
PO : 1-2 mg/kg/day in 2-4 divided dose ; Max 150-200 mg/day
Drug
Pediatric Dose
Iron supplement
Severe Fe deficiency :PO 4-6 mg Fe/kg/day in 3 divided dose
Mild-moderate Fe deficiency : PO 3 mg Fe/kg/day in 1-2 divided dose
Prophylaxis : PO 1-2 mg Fe/kg/day ; Max 15 mg/day
( Ferrous fumarate 33 % , gluconate 11.6 % , sulfate 20 % )
Isoniazid
Treatment : PO 10-20 mg/kg/day in 1-2 divided dose ; Max 300 mg/day
Prophylaxis : PO 10 mg/kg/day once daily ; Max 300 mg/day
Itraconazole
HIV-pt : PO 2-5 mg/kg/dose q 12-24 hrs
Kanamycin
IV,IM 15-30 mg/kg/day divided q 8-12 hrs
Kaolin and pectin
PO :3-6 y : 15-30 ml/dose ; 6-12 y : 30-60 ml/dose
Ketoconazole
PO : 3.3-6.6 mg/kg/day once daily ; Max 800 mg/day divided twice daily
Prophylaxis in HIV-pt : PO 5-10 mg/kg/day
Ketotifen ( 1 mg/5ml)
PO :> 2y ;1mg twice daily
Levothyroxine
0-6 mo : PO 8-10 mcg/kg or 25-50 mcg
6-12 mo : PO 6-8 mcg/kg or 50-75 mcg
1-5 y : PO 5-6 mcg/kg or 75-100 mcg
6-12 y :PO 4-5 mcg/kg or 100-150 mcg
> 12 y : PO 2-3 mcg/kg or > 150 mcg
Lincomycin
IV,IM : 10-40 mg/kg/day divided q 8-12 hrs
Loperamide
PO : 2-5 y ; 1 mg tid , 6-8 y ; 2 mg bid , 8-12 y ; 2 mg tid
Mebendazole ( 20 mg/ml)
PO :100 mg twice daily x 3 days ( Capillariasis 200 mg twice daily for 20 days )
Methimazole
PO : 0.2 mg/kg/day in 3 divided dose
Metoclopramide
PO ,IV,IM : 0.4-0.8 mg/kg/day in 4 divided dose
Drug
Pediatric Dose
Metronidazole
PO,IV : 30 mg/kg/day divided q 6 hrs ; Max 4 gm/day
Naproxen
Analgesia : PO 5-7 mg/kg/dose q 8-12 hrs
Inflam : PO 10-15 mg/kg/day in 2 divided dose ; Max 1000 mg/day
Netilmicin
IV,IM : 5-7.5 mg/kg/day divided q 8 hrs
Norfloxacin
PO : 15-20 mg/kg/day
Nystatin
Oral candidiasis : Neonate : 100000 unit 4 times/day
Infant : 200000 unit 4 time /day , Children 400000-600000 unit 4 time/day
Paracetamol
Neonate : PO 10-15 mg/kg/dose q 6-8 hrs
Infant - 12 y : PO 10-15 mg/kg/dose q 4-6 hrs
> 12 y - adult : 325 - 650 mg q 4-6 hrs ; Max 4 gm/day
Penicillin G
IM,IV : 100000-250000 unit /kg/day in divided q 4-6 hrs ( Severe 250000-400000 unit/kg/day q 4-6 hrs ; Max 24 mu/day )
Penicillin V
PO : 25-50 mg/kg/day in divided q 6-8 hrs ; Max 3 gm/day
Phenobarbital
( 20mg/5ml)
Infant : PO ,IV : 5-6 mg/kg/day in 1-2 divided dose
1-5 y : PO ,IV : 6-8 mg/kg/day in 1-2 divided dose
5-12 y : PO ,IV : 4-6 mg/kg/day in 1-2 divided dose
> 12 y : PO ,IV : 1-3 mg/kg/day in 1-2 divided dose
Piperacillin
< 12 y ; FDA not approved : IV,IM : 200-300mg/kg/day divided q 4-6 hrs ; Max 24 gm/day
Piroxicam
PO : 0.2-0.3 mg/kg/day once daily ; Max 15 mg/day
Prednisolone
Acute asthma : PO 1-2 mg/kg/day ; IV 2-4 mg/kg/day
Anti-inflam. : PO,IV : 0.1-2 mg/kg/day
Primaquine ( 15 mg base ) 0.3 mg base/kg/day once daily for 14 day ; Max 15 mg base/day
Procaine Pen G (PPF)
IM : 25000 - 50000 unit/kg/day divided q 12-24 hrs ; Max 4.8 mu /day
Drug
Pediatric Dose
Promethazine
PO,IM,IV : 0.25-1 mg/kg/ 4-6 times/day
Pseudoephedrine
PO : < 2 y : 4 mg/kg/day divided q 6 hrs
2-5 y : 15 mg q6 hrs ; Max 60 mg/day
6-12 y : 30 mg q 6 hrs : Max 120 mg/day
> 12 y : 60 mg q 6 hrs : Max 240 mg/day
Pyrazinamide
PO : 20-40 mg/kg/day ; Max 2 gm/day
Ranitidine
PO : 4-5 mg/kg/day divided q 8-12 hrs ; Max 300 mg/day
IM,IV : 2-4 mg/kg/day divided q 6-8 hrs
Rifampin
PO : 10-20 mg/kg/day , divided q 12-24 hrs
Salbutamol
2-6 y : PO 0.1 - 0.2 mg/kg/dose TID ; Max 12 mg/day
6-12 y : PO 2 mg/dose TID - QID ; Max 24 mg/day
>12 y - adult : PO 2-4 mg/dose TID - QID ; Max 32 mg/day
Nebulizer : < 5Y ; 1.25-2.5 mg q4-6 hrs , > 5 y 2.5-5 mg q 4-6 hrs ; Max 5 mg/dose or 0.01-0.05 ml/kg of 0.5 % solution
q 4-6 hrs ; Max 1 ml
Inhaler : < 12 y : 90-180 mcg QID
> 12 y : 90-180 mcg q 4-6 hrs ; Max 12x90 mcg/day
Simethicone
< 2 y , PO : 20 mg 4 time/day
2-12 y : PO 40 mg 4 time/day
> 12 y : PO 40-125 mg 3-4 time/day ; Max 500 mg/day
Streptomycin
IM : 20-40 mg/kg/day ; Max 1 gm/day
Sucralfate
not established ; 40-80 mg/kg/day divided q 6 hrs
Pediatric Dose
Terbutaline
< 12 y , PO : 0.05-0.15 mg/kg/dose q 8 hrs ; Max 5 mg/day , SC: 0.005-0.01 mg/kg/dose ; Max 0.4 mg /dose q 15-20
min for 2 dose
> 12 y , PO : 2.5-5 mg/dose q 6-8 hrs ; Max 7.5 mg/dose ( > 15 y , Max 15 mg/dose ) , SC : 0.25 mg/dose repeat in 15-
30 min
Tetanus antitoxin
Prophylaxis : IV ,IM : < 30 kg : 1500 unit , >30 kg 3000 - 5000 unit
Tetracycline
< 8 y not recommened
> 8 y , PO : 25-50 mg/kg/day divided q 6 hrs ; Max 3 gm/day
Theophylline
< 1 y , PO : 10-18 mg/kg/day
1-9 y , PO : 20-24 mg/kg/day
9-12 y , PO : 16 mg/kg/day
12-16 y , PO : 13 mg/kg/day
Thiabendazole
PO : 50 mg/kg/day ; Max 3 gm/day
Triprolidine + Pseudo.
PO : 4 mg of pseudo /kg/day divided 3-4 time/day
Vancomycin
IV : 40 mg/kg/day divided q 6-8 hrs
เอกสารอ้างอิง : 1. Pediatric dosage Handbook , 1998-1999
2. Lacy FC, Armstrong LL, Goldman MP, Lance LL. Drug information handbook international. 12 th ed. Ohio: Lexi-Comp, 2004.
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