Gout
Drugs commonly used for treatment of gout
Acute attack
NSAIDs
Indomethacin (Indocin), 50-75 mg PO initially, then 50 mg q6h, tapered over 7 days
Ibuprofen, 800 mg q8h, tapered over 7 days
Colchicine, 0.6 mg PO q1-2h (maximum, 4 mg/24 hr)
Corticosteroids
Prednisone, 0.5-0.75 mg/day PO, tapered over 7 days
Triamcinolone acetonide, 10-40 mg intra-articularly, depending on size of joint
Corticotropin, 40-80 IU IM q24-72h
Prevention of recurrence
Colchicine, 0.6 mg/day PO
NSAIDs
Indomethacin, 50 mg bid
Ibuprofen, 400-800 mg q8h
Reduction of uric acid levels
Probenecid (Benemid, Benuryl), 250 mg bid x 7 days,
increased to 500-1,000 mg bid for maintenance dosage
Sulfinpyrazone (Anturane), 50 mg bid x 7 days,
advance to 100 mg bid;
maintenance dosage, 200 mg bid
Allopurinol (Purinol, Zyloprim), 300-600 mg/day,
adjusted according to renal function (ie, GFR)*