Gout

Drugs commonly used for treatment of gout

Acute attack

NSAIDs

Indomethacin (Indocin), 50-75 mg PO initially, then 50 mg q6h, tapered over 7 days

Ibuprofen, 800 mg q8h, tapered over 7 days

Colchicine, 0.6 mg PO q1-2h (maximum, 4 mg/24 hr)

Corticosteroids

Prednisone, 0.5-0.75 mg/day PO, tapered over 7 days

Triamcinolone acetonide, 10-40 mg intra-articularly, depending on size of joint

Corticotropin, 40-80 IU IM q24-72h

Prevention of recurrence

Colchicine, 0.6 mg/day PO

NSAIDs

Indomethacin, 50 mg bid

Ibuprofen, 400-800 mg q8h

Reduction of uric acid levels

Probenecid (Benemid, Benuryl), 250 mg bid x 7 days,

increased to 500-1,000 mg bid for maintenance dosage

Sulfinpyrazone (Anturane), 50 mg bid x 7 days,

advance to 100 mg bid;

maintenance dosage, 200 mg bid

Allopurinol (Purinol, Zyloprim), 300-600 mg/day,

adjusted according to renal function (ie, GFR)*