The Regulons of Atra
Dr. Ayad Hazim Hasan
ayad.hasan@cihanuniversity.edu.iq
Abstract- Bacteria of the genus Streptomycin have been a rich source of antibiotics, in addition to antiphonals, antivirals and anti-tumourals. Indeed 80% of the antibiotics in clinical or veterinary use are derived from the metabolism of Streptomycin. Streptomycin coelicolor is used as a model for studying the regulation of secondary metabolism and morphological development. Previous work has identified a transcription factor called AtrA that regulates the production of actinorhodin, a pigment antibiotic. A combination of in vitro and in silico studies suggests that AtrA may control the metabolism of acetyl CoA, which is a precursor for several important classes of natural products.
Keywords- AtrA, Acetyl CoA, Streptomycin
Date: 04/05/2018
Place: Department of Biology