The Protective Role of Omega-3 and Melatonin Against AICl3
Dr. Khabat Anwar Ali
Abstract- The aim of the present study was to demonstrate the protective role of omega-3, melatonin and their combination against AlCl3 induced some biochemical changes especially (OS, lipid peroxidation and AD) markers in serum of experimental rats. Forty adult female rats were used in this present study. They were divided randomly into five groups, each group with eight rats. G1: considered as a control group. G2: (1000mg/L drinking water) AlCl3. G3: (1000mg/L drinking water) AlCl3 + omega-3 oil (4000mg/kg diet). G4: (1000mg/L drinking water) AlCl3 + melatonin (50mg/kg diet). G5: (1000mg/L drinking water) AlCl3 + omega-3 oil (4000mg/kg diet) + melatonin (50mg/kg diet). All the above groups left for 40 days. In conclusion AlCl3 caused many biochemical changes in of albino rats, while omega-3, melatonin either alone or together showed a protective role against AlCl3 toxicity. This protection could be through the antioxidant and anti-amyloidal role of omega-3 and melatonin.
Keywords-Omega-3; Melatonin; AlCl3; Toxicity
Date: 13/12/2017
Place: Biology department, Hall No. 303