Vecuronium

Keyword

Vecuronium

Physical structure

pancuronium minus a quaternary methyl group.

Metabolism

by the liver

Excretion

primaryily on biliary excretion

secondarily on renal excretion

Characteristics

long-term administration of vecuronium to patients in ICU has resulted in prolonged neuromuscular blockade(up to several days)

• Risk factors of prolonged neuromuscular blockade
• female gender
• renal failure
• long-term or high-dose corticosteroid Tx
• sepsis

Dose

Intubating dose : 0.08-0.12 mg/kg

maintenance dose

• IV bolus : initial로 0.04 mg/kg -> 15-20분마다 0.01mg/kg씩 준다
• Continuous infusion : 1-2 mcg/kg/min

Reference