Keyword
Neostigmine & Pyridostigmine
Mechanism
Specific Cholinesterase inhibitors
Dose
- Neostigmine
- mild-to-moderate muscle relaxation : 0.04 mg/kg (or 2.5 mg)
- intense muscle relaxation : 0.08 mg/kg (or 5 mg)
- maximal dose : 5 mg
- Pyridostigmine
- 0.2 mg/kg (total 20mg in adult)까지 쓸 수 있음.
Prior or concomitant administration of an anticholinergic agent
- muscarinic side effect를 최소화하기 위하여 anticholinergic agent를 함께 투여.
- Neostigmine
- 0.2mg glycopyrrolate (mobinul) per 1mg neostigmine
- Pyridostigmine
- 0.05mg glycopyrrolate per 1mg pyridostigmine
- 0.1 mg atropine per 1mg pyridostigmine
Reference
Miller’s Anesthesia, 8th edition, Ch.35, P.1006,