Esmolol

keyword

Esmolol

Treatment

• esterase 에 의해 가수분해되어 반감기는 9-10분으로 매우 짧아 마취중에 특히 유용하다

• 최대효과는 loading dose 주입 후 5-10분 안에 나타나고 20-30분 사이에 급격히 사라진다.

• bolus : 0.5 mg/kg to blunt cardiovascular responses to tracheal intubation.

• verapamil 에 비해서 esmolol 은 atrial fibrllation을 sinus rhythm 으로 더 잘 전환시킨다.

* 심실위 빠른맥 치료 :

• 500 μg/kg is given over a 1-minute period, followed by an infusion of 50 μg/kg/minute for 4 minutes
• If not controlled, a repeat loading dose followed by a 4-minute infusion of 100 μg/kg/minute is given
• this sequence is repeated with the infusion increased in 50 μg/kg/minute increments up to 200 or 300 μg/kg/minute if needed
• The effect may persist for 20 to 30 minutes after discontinuation of the infusion

Reference

Miller’s Anesthesia, 8th edition, Ch.16, P.375.