Keyword
Fibrinogen concentrate
Character
Human plasma에서 추출되며 의미있는 정도의 다른 coagulation factors는 없음.
No complication associated with blood transfusions
First-line therapy to reduce transfusion requirements
Conventional blood products vs fibrinogen concentrate
Improve hemostasis more rapidly than conventional allogeneic blood products
Lower risk for immunologic reactions, infection, intravascular volume overload
Single dose of 4 g of fibrinogen -> blood level fibrinogen 200 mg/dL
Reduce the incidence of platelet administration
For the treatment of perioperative coagulopathy in bleeding patients -> 큰 이점없음
Reference
Miller’s anesthesia, 8th edition, Chapter 61: Patient Blood Management: Transfusion Therapy, P.1861