Amiodarone

Keyword

Amiodarone

Definition

Class III antiarrhythmic agent ( but, its effects overlap those of other classes of antiarrhythmics)

Indication

refractory life-threatening arrhythmias

• fatal arrhythmias ( WPW syndrome, AF, VT )
• recurrent cardiac arrest
• HF

Treatment

• Administered in one or more dosesof 150 mg given IV in 100 mL saline or D5W over 10 minutes
• Followed by an IV infusion of 1 mg/min for 6 hours
• And 0.5 mg/min thereafter, is the recommended current treatment (maximum IV dose 2.2 g/24 hr).
• onset of action of amiodarone after a single intravenous dose : between 1 and 30 minutes
• duration : 1 and 3 hours

Reference

Miller’s Anesthesia, 8th edition, Ch.47( P.1444), Ch108.(P.3197)

Cardiac drug therapy ,M.Gabriel Khan. 6th edition, P.344

Clin Pharmacokinet. 1984 Mar-Apr;9(2):136-56.” Clinical pharmacokinetics of amiodarone. “ Latini R, Tognoni G, Kates RE