Atracuruim, Cisartracurim

Keyword

Atracurium & Cisartracurium

Atracurium

Action

• intubating dose : 0.5mg/kg
• onset for intubatation : 2.5~3.0min
• duration : 30~45min
• maintenance dosing by bolus : 0.1mg/kg
• maintenance dosing by infusion : 5-12mcg/kg/min

Profit

• good or excellent intubation condition (v/s unstable로 pofol 소량투여시 병용가능)

Side effect

• Histamine release
• HypoT, tachycardia
• bronchospam
• Laudanosine toxicity (CNS excitation, MAC elevation, seizure)

Cisartracurium

Action

• intubating dose : 0.2mg/kg
• onset for intubatation : 2.0~3.0min
• duration : 40~75min
• maintenance dosing by bolus : 0.02mg/kg
• maintenance dosing by infusion : 1-2mcg/kg/min

Character

• steroidisomer of atracurium

Profit

• metabolism and elimination are independent of ranal or liver failure (CRF 환자에서 적합)

Reference