Succinylcholine

Keyword

Succinylcholine

Mechanism

depolarizing NMBD(neuromuscular blocking drugs)

(1) desensitization of the nAChR

(2) inactivation of voltage-gated Na+ channels at the NM junction

(3) increases in K+ permeability in the surrounding membrane.

-> failure of action potential generation and neuromuscular blockade.

Dose

• intubating dose : 0.5 to 0.6 mg/kg~1.0 mg/kg
• onset for intubation : 30secs
• duration : 5-10mins

Characteristics

• rapid onset of effect
• the profound depth of neuromuscular blockade
• short duration of action

Side effect

• autonomic stimulation : sinus bradycardia, junctional rhythms, and ventricular dysrhythmias
• HyperK+
• Fasciculation
• Increased Intraocular Pressure(IOP)
• Increased Intragastric Pressure(IGP)
• Increased Intracranial Pressure(ICP)
• Myalgias
• Masseter Spasm
• Malignant hyperthermia

Etc.

after administering succinylcholine for intubation, a nondepolarizing NMBD is given to maintain NM blockade.

Reference