All these ladies got together many times, chatted over several meetings having pumpkin spice ambrosia, and they hatched a plan, manufactured six macguffins, and then organized a huge multiversal cosmic festival on the outer planes, allegedly celebrating the 4000th year of Rovagug's imprisonment. All were invited, many many gods attended.
At the climax of the festival dinner, Nike pulled the lever, taking hundreds of divine lives with her, since noone suspected her of being suicidal.
She took with her all the stupid gods of Golarion, the poorly designed cultures, the ripoffs of other gameworlds, the plagiarism (Osirians) and everything else related went down the cosmic toilet. And all the citizens and civilians living on Golarion went away also. Millions of them. This was okay since many of those flushed were stupid and uneducated enough to worship in cults, or unwise enough to see the differences between Osirian, Qliphothic, Wanshou, Qadira, and the actual factuals, which the authors had poorly mirrored.
Hundreds of thousands of devils, chaos demons, and other foul creatures, who had illegally immigrated onto Golarion were also wiped away, so this made many happy. Since the ratio of the stupid, edgy, murder-hobos, other evil player-characters , the possessed, min-maxers, and self-destructive was so high relative to the good beings also lost, the Cosmic Flush was labeled by the higher powers judging the act as a reasonable war campaign against chaos.
Some side effects from the Ladies masterplan were unforeseen, thus the Gap.
Now this destruction seemed like terrorism and mass-murder to many, but the Ladies were forgiven, since .....
A: most of them were now gone from the cosmos as well...
B: they had flushed away several trillion metric tons of shyte, especially evil gods and cults.
Many folks were saddened at the loss of the good goddesses, but had to chin up, and man-up, and realize the epic level of their heroics. Since they sacrificed themselves to destroy so much evil, totally worth it.
Sadly, some extremely minor flaws in their plan have allowed chaotic junk to leak back into the universe (such as the crud of Aucturn). Also the "backdoors" Hecate crafted into the Gap were imperfectly coded, and so the viewing restrictions and time-travel permissions became interwoven and garbled. But thankfully the vast majority the filth they did absolutely blast away has remained gone.