Lecturer: Shih-Chao Lin (林士超)
Email: sclin@mail.ntou.edu.tw
Phone: (02) 24622192 # 5804
Webpage: https://imme.ntou.edu.tw/p/412-1117-11539.php?Lang=zh-tw
Course ID: M3C014XD
Credits: 3
Objective: This advanced course covers a range of topics in marine biotechnology, focusing on the various biotechnological methods currently used to explore marine animals, plants, and microbes. The course will include discussions on marine biotechnology''s applications in areas such as marine pollution, ecology, psycology, and microbiology. The primary goal is to provide a comprehensive understanding of contemporary approaches used in the discovery and advancement of knowledge in marine sciences.
Course Prerequisites: None
Outline:
Part I: This part is designed for students with a background in organic chemistry and biochemistry, and it focuses on introducing the design of marine drugs and their mechanisms of action within the body. The course begins by exploring the functional groups of organic small molecules. It then introduces the structure and function of biomolecules in cells. Next, it covers how small organic drug molecules interact with biomolecules and their mechanisms of action. Finally, it discusses the development process of marine drugs and various design strategies for cancer drugs.
Part II: This part contains lecturing and discussion regarding the journal papers assigned to students before classes. The topics for discussion cover marine prokaryotes, marine eukaryotes, marine viruses, fish vaccine development, exploration and utilization of marine bioresources, application of bioinformatics in marine bioresearch, and introduction to marine biotechniques.
Teaching Method: blackboard-writing, PowerPoint, textbook
Reference:
Part I: An Introduction to Medicinal Chemistry, Fifth Edition- Graham L. Patrick. ISBN: 978-0-19-969739-7
Part II: TBD
Course Schedule (subject to change):
Part I:
1. Introduction to the process of marine drugs development
2. Functional groups for small organic molecules
3. Noncovalent interactions
4. Lipids as drug targets
5. Carbohydrates as drug targets
6. Nucleic acid as drug targets
7. Proteins as drug targets
8. Midterm exam
Part II:
9. Marine microorganisms
10. Maine viruses
11. Development of fish vaccines
12. Exploration and utilization of marine bioresources
13. Bioinformatics in Marine bioresearch
14. Marine biotechniques
15. Seminar by guest speaker
16. Final exam
Evaluation:
Midterm (30%)
Final exam (30%)
Participation in class (30%)
Assignment (10%)