Post date: Jan 21, 2020 4:25:13 PM
Task done today:
- Read An abundance of rare functional variants in 202 drug target genes sequenced in 14002 people, Science Reports 2012
- Heterozygosity expected and observed
A- AC/AN gives a rough estimation of the allele frequency: p.
2pq = 2*p*(1-p) estimates the expected heterozygosity.
B- Count the number of observed heterozygotes per SNP and divide by total number of individuals having reads for this SNP: observed heterozygosity.
Histograms where I overlay A and B: Plots can be seen here.
- Lab meeting Atlanta
- Learning more about MEM
https://mb3is.megx.net/gustame/spatial-analysis/pcnm
https://sites.ualberta.ca/~ahamann/teaching/renr690/Lab9.pdf