You can choose from using one speaker or a couple of speakers of different sizes. The larger speaker (100mm) can produce a louder sound, with a good deep bass sound. The smaller speaker (60mm) is often used for the 'high end' treble (vocals) sound. Yoou can use a speaker individually; as a pair; or as a combination of large and small speakers (this is usually done in a vertical alignment). You could also use two large speakers but this comes at a cost (you have to pay for the additional speaker).
You could even add a third speaker (in your own time). This would be the SubWoofer and could be a totally different design, which you would need to research and then manufacture.
If you wish to see the 3D CAD file of the speaker then click on this link - Speaker Working drawing
If you wish to see the 3D CAD file of the small speaker then click on this link - Small Speaker Working Drawing
As previously mentioned, adding feet to the bottom of the design will reduce vibration and ultimately help to produce a better sound. This also allows for you to have even more design input
Instead of just having a hole at the back of the speaker for the wires to join the speaker, it can look neater and also make it easier to join to the amplifier if you use a speaker connector or terminal.
You could add and use decorative patterns for speaker grills
Try to think about how you can make the side panels of your design look stylish, clean and modern. Can you add any form of pattern? Could you add a cut or change of surface direction?
Add. in images of different dials and options
Sound padding - this will change the sound to become higher quality. The more you can reduce vibration the better your speaker will sound.