Large B-cell lymphomas

Subtypes of LBCL (18 subtypes):

  • Diffuse large B-cell lymphoma, NOS

  • T-cell/histiocyte-rich large B-cell lymphoma

  • Diffuse large B-cell lymphoma/ high grade B-cell lymphoma with MYC and BCL2 rearrangements

  • ALK-positive large B-cell lymphoma

  • Large B-cell lymphoma with IRF4 rearrangement

  • High-grade B-cell lymphoma with 11q aberrations

  • Lymphomatoid granulomatosis

  • EBV-positive diffuse large B-cell lymphoma

  • Diffuse large B-cell lymphoma associated with chronic inflammation

  • Fibrin-associated large B-cell lymphoma

  • Fluid overload-associated large B-cell lymphoma

  • Plasmablastic lymphoma

  • Primary large B-cell lymphoma of immune-privileged sites

  • Primary cutaneous diffuse large B-cell lymphoma, leg type

  • Intravascular large B-cell lymphoma

  • Primary mediastinal large B-cell lymphoma

  • Mediastinal grey zone lymphoma B-cell lymphoma

  • High-grade B-cell lymphoma, NOS

Summary of the relationship between LBCL entities as named and defined in the WHO 4 and in the present WHO5