Flow

B-CLPD

Kleur-gecodeerde tabel waarin de mean fluorescence intensity scores per eiwitkleuring weergegeven worden per B cel maligniteit (bron: Euroflow).

BL= B cel leukemie; CLL = chronische lymfatische leukemie; DLBCL = diffuus grootcellig B cel lymfoom; FL = folliculair lymfoom; HCL = hairy cell leukemie; LPL = lymfoplasmocytair lymfoom; MCL = mantelcel lymfoom; MZL = marginale zone lymfoom.

T/NK-CLPD

T-lineage antigens

CD2: pan T antigen. Synoniem: LFA2
CD3: the T-cell receptor (TCR) requires the CD3 complex to be expressed and be able to activate upon antigen recognition.
- cytoplasmatic (cyCD3) versus cell membrane (SmCD3)
- immature T cells express CyCD3 only, that the combined expression of CyCD3 and SmCD3 is characteristic for intermediate differentiation stages, and that mature T cells express prominent SmCD3.
CD4: TCR co-receptor
CD8: TCR co-receptor
CD5: pan T antigen
CD7: pan T antigen. also appears on early T-cells at a stage where it is possible for these cells to reverse to the myeloid lineage (denk aan abberante expressie in AML).
CD1a: characteristic of maturing T-cells located in the thymus cortex

Nb CD6 is ook een T-cel marker

in LST: CD45, CD4 en smCD3
ook CD8, CD5 en TCRyd

Backbone T-CLPD: CD45, CD4 en SmCD3 (cell membrane expression)
ook CD2, CD7, CD8

NK-lineage antigens

NK-cells have long been thought to be devoid of surface antigens and were for a time called 'nude lymphocytes'.
Most commonly used to define NK-cells; CD16 and CD56.
Overig: CD57, KIRs, CD94, CD158, CD160 en CD161