• Voltage-dependent anion channel 1

• Autophagy

• Mitochondrial function

• Regulatory role for opening of mitochondrial permeability transition pore (mPTP)

• Phosphorylated on Ser104 by SKG-1 to promote its degradation

• Accumulation of VDAC-1 induces autophagy

• Enhanced autophagy not beneficial for lifespan extension with increased mitochondrial permeability in C. elegans

Zhou (2019)