• Apolipiprotein E

• Lipid metabolism

• Apolipo-proteins, gene gives rise to three main protein variants: APOE2, APOE3, APOE4. APOE3 functions include assisting in maintaining structural integrity of cholesterol-rich lipoproteins, regulates lipid homeostasis in hepatic and non-hepatic tissues. APOE4 gene associated with increased risk of AD

• Gene consistently associated with longevity in multiple independent studies. E4 associated with increased risk of death that persists beyond ages reached by less than 1% of the population

• KO expression of APOE leads to shortened lifespan due to increase in age-related phenotypes ie. Altered lipoprotein profile, type II diabetes, immune response, elevated oxidative stress

Broer (2015), Abondio (2019)