• Mammalian Target of Rapamycin Complex 1

• mTOR

• Environmental sensor, integrates signals from environmental cues to promote anabolic and inhibit catabolic cellular functions. Activated by insulin and other growth factors through PI3K/AKT signalling, repressed by AMPK. Contains Raptor, promotes protein synthesis through S6Ks and 4E-BP1. Also promotes lipid biosynthesis, represses degradation through autophagy pathway, regulate glucose metabolism and mitochondrial function through HIF-1α, and PGC-1α

• Central and conserved regulator of longevity

Johnson (2013)