• Lysosomal acid lipase 4

• Lysosomal signalling

• Similarities to human LIPA

• Breakdown of lipids in lysosome, overexpression in worms produces increased amounts of oleoylethanolamide

• Increased expression of LIPL-4 increased longevity in C. elegans, depending on the presence of LBP-8

• Increases mitochondrial b-oxidation to reduce lipid storage and promote longevity

Folick (2015), Ramachandran (2019)