Embedded Files
FOXO
Name
Name
Forkhead box O
Relevant Pathway
Relevant Pathway
Function
Function
Downstream effectors of IIS pathway, cause metabolic shift from glucose to lipid oxidation, enhancement of cellular stress resistance, suppression of low grade inflammation, and enhanced mitochondrial biogenesis. Consists of FOXO1, FOXO3, FOXO4, FOXO6
FOXO3 and FOXO4 directly deacetylated by SIRT
Role in Longevity
Role in Longevity
Regulation of genes in autophagy and mitophagy, resistance to oxidative stress, role in stem cell biology and tissue homeostasis. Genetic variation in FOXO3A associated with human longevity
Reference
Reference
López-Otín (2013), Heemst (2010), Broer (2015), Martins (2016)
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