Embedded Files
Salermide
IUPAC Name: N-[3-[(2-hydroxynaphthalen-1-yl)methylideneamino]phenyl]-2-phenylpropanamide
Chemical Formula: C26H22N2O2
Chemical Formula: C26H22N2O2
Exact Mass: 394.17 g/mol
Exact Mass: 394.17 g/mol
Molecular Weight: 394.5 g/mol
Molecular Weight: 394.5 g/mol
Elemental Analysis: C(79.16%) H(5.62%) N(7.10%) O(8.11%)
Elemental Analysis: C(79.16%) H(5.62%) N(7.10%) O(8.11%)
SMILES: CC(C1=CC=CC=C1)C(=O)NC2=CC(=CC=C2)N=CC3=C(C=CC4=CC=CC=C43)O
SMILES: CC(C1=CC=CC=C1)C(=O)NC2=CC(=CC=C2)N=CC3=C(C=CC4=CC=CC=C43)O
PubChem CID: 135659046
Chemical Structure:
Alternative Names
Alternative Names
Source
Source
Drug
Protein Target/Signalling
Protein Target/Signalling
SIRT1
SIRT2
Biological Pathway
Biological Pathway
Epigenetic modification
Longevity-Related Effects/Anti-ageing mechanism
Longevity-Related Effects/Anti-ageing mechanism
Biological Activity
Biological Activity
Reverse amide with strong in vitro inhibition of SIRT1 and SIRT2, well tolerated by mice, tumour-specifc cell death in range of human cell lines
Reference
Reference
Lara (2009), Villalba (2012)
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