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PGC-1α
Name
Name
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Relevant Pathway
Relevant Pathway
Function
Function
Regulates mitochondrial function, antioxidant defenses, and fatty acid oxidation
Role in Longevity
Role in Longevity
Activation enhances antioxidant defenses and improves fatty acid oxidation
Can be activated by SIRT1 and AMPK
Reference
Reference
López-Otín (2013), Wu (1999)
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