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Nicotinamide adenine dinucleotide
Chemical Formula: C21H27N7O14P2
Chemical Formula: C21H27N7O14P2
Exact Mass: 663.11 g/mol
Exact Mass: 663.11 g/mol
Molecular Weight: 663.4 g/mol
Molecular Weight: 663.4 g/mol
Elemental Analysis: C(38.02%) H(4.10%) N(14.78%) O(33.76%) P(9.34%)
Elemental Analysis: C(38.02%) H(4.10%) N(14.78%) O(33.76%) P(9.34%)
SMILES: C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
SMILES: C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
PubChem CID: 5892
Chemical Structure:
Alternative Names
Alternative Names
NAD+
Source
Source
Metabolism cofactor
Protein Target/Signalling
Protein Target/Signalling
Sirtuins
PARPs
Biological Pathway
Biological Pathway
Epigenetic modification
Longevity-Related Effects/Anti-ageing mechanism
Longevity-Related Effects/Anti-ageing mechanism
Healthspan and lifespan extension in various animal models
Regulator of sirtuins
Biological Activity
Biological Activity
Ubiquitous metabolite in the catabolism of nutrients, cosubstrate for sirtuins, PARPs, and cyclic ADP-ribose synthases. Decline of NAD+ levels in a number of tissues with ageing and overnutrition
Reference
Reference
Sultani (2017), Rajman (2018)
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