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JAK2
Name
Name
Janus kinase 2
Relevant Pathway
Relevant Pathway
Function
Function
Member of JAK family, acts through downstream STAT proteins to control biological events
JAK1 and 2 have essential roles in inflammatory signalling and regulating growth hormone and other endocrine signals
Role in Longevity
Role in Longevity
JAK pathway inhibition suppresses SASP in senescent cells and alleviates age-related tissue dysfunction
Reference
Reference
Xu (2016), Rawlings (2004)
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