• Mitochondrial permeability transition pore

• Autophagy

• Opening of MPTP pore enables free passage of molecules < 1.5 kDa into mitochondria (incl protons) leading to ATP depletion and necrotic cell death. Transient opening regulates calcium and ROS signalling

• Elevated autophagy and mPTP opening shorten lifespan in sgk-1/mTORC2 mutant worms

Halestrap (2009), Zhou (2019)