• Mammalian Target of Rapamycin Complex 2

• mTOR

• Activated by insulin, but unlike mTORC1 activity is not regulated by amino acids. Contains Rictor in place of Raptor, phosphorylates Akt

• With downstream S6K1 in c. elegans, suppression of maladaptive autophagy to reduce mPTP opening

• Insensitive to acute rapamycin treatment, regulation not as well understood

Zhou (2019), Garcia-Martinez (2008), Johnson (2013)