• Sirtuin 1

• Epigenetic modification

• Metabolic responses to changes in nutritional availability and maintain physiological homeostasis in mammals

• Sirtuins sense low-energy states by detecting high NAD+ level

• Activates mitochondrial biogenesis through AMPK, HIF-1α, and PCG-1α

• Downregulation of inflammation-related genes

• Hypothalamic SIRT1 functions as key mediator of neurobehavioural adaptive response to DR

• Overexpression of SIRT1 in mice significantly extends lifepsan and exhibits phenotypes associated with delayed ageing

• Homolog to invertebrate Sir2, studied with resveratrol

• Predominately localised in nucleus, shuttled to cytosol

López-Otín (2013), Satoh (2010), Satoh (2013), Yuan (2016)