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SIRT3
Name
Name
Sirtuin 3
Relevant Pathway
Relevant Pathway
Function
Function
Mitochondrial deacetylase that targets enzymes in energy metabolism, including nutrient oxidation, ATP generation, ROS detoxification, mitochondrial dynamics, and mitochondrial unfolded protein response
Can control rate of ROS production
Role in Longevity
Role in Longevity
Controls mitochondrial function
Mice lacking SIRT3 develop several diseases of ageing at accelerated rates
Reference
Reference
López-Otín (2013), McDonnell (2015)
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