• Histone deacetylase 8

• Epigenetic modification

• Superfamily of proteins classified into four families: class I (HDAC1, 2, 3, 8), IIa (HDAC4, 5, 7, 9), IIb (HDAC6, 10), and IV (HDAC11). Also encompass sirtuins (class III)

• Genes encoding HDACs known to be involved in regulation of lifespan in different organisms, HDAC inhibitors promising

Haberland (2009), Pasyukova (2017)