• Sirtuin 2

• Epigenetic modification

• Binds to HDAC6 and deacetylates α-tubulin, participating in the regulation of microtubule dynamics and potentially cell cycle progression

• SIRT2 deacetylates transcription factor p65 at LYS310 to regulate NF-κB dependent gene expression

• SIRT2 induces the checkpoint kinase BubR1 to increase lifespan in mice

• Sirt2 inhibited the p53/p21 pathway and oxidative stress in nucleus pulposus cells

• Localised in cytoplasm

López-Otín (2013), Yang (2019), Rothgiesser (2010), North (2014)