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Metformin
Chemical Formula: C4H11N5
Chemical Formula: C4H11N5
Exact Mass: 129.10 g/mol
Exact Mass: 129.10 g/mol
Molecular Weight: 129.16 g/mol
Molecular Weight: 129.16 g/mol
Elemental Analysis: C(37.20%) H(8.58%) N(54.22%)
Elemental Analysis: C(37.20%) H(8.58%) N(54.22%)
SMILES: CN(C)C(=N)N=C(N)N
SMILES: CN(C)C(=N)N=C(N)N
PubChem CID: 4091
Chemical Structure:
Alternative Names
Alternative Names
Source
Source
Drug
Protein Target/Signalling
Protein Target/Signalling
AMPK
Biological Pathway
Biological Pathway
mTOR
IGF/IIS
Epigenetic modification
Longevity-Related Effects/Anti-ageing mechanism
Longevity-Related Effects/Anti-ageing mechanism
CR mimetic
Mild mitochondrial poison inducing mitohormesis
Indirect activation of AMPK by inhibiting Complex I in the respiratory chain
Biological Activity
Biological Activity
Healthspan benefits mimicking caloric restriction, FDA approved clinical trial underway (Targeting Aging with Metformin, TAME). Frontline therapy for type 2 diabetes patients
Reference
Reference
López-Otín (2013), Sen (2016), Chen (2011), Luengo (2014)
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