Embedded Files
AMPK
Name
Name
Adenosine monophosphate-activated protein kinase
Relevant Pathway
Relevant Pathway
Function
Function
Senses low energy states by detecting high AMP levels
Controls autophagy through mTOR and ULK1 signalling
Role in Longevity
Role in Longevity
Negatively regulates mTORC1
Stimulation of FOXO/DAF-16, Nrf2/SKN-1, and SIRT1 signalling for improvement of cellular stress, inhibition of NF-κB signalling for suppression of inflammatory response
Reference
Reference
Salminen (2012a), Johnson (2013), López-Otín (2013), Salminen (2011)
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