• Transient receptor potential cation channel subfamily V member 1

• Transient receptor potential vanilloid 1

• MAPK

• Nociception

• Stimulation releases neuropeptides, substance P to promote neurogenic inflammation and calcutonin gene-related peptide (CGRP) to antagonise insulin release in in vivo assays

• Mice lacking TRPV1 pain receptors are long-lived with youthful metabolic profile at old age, regulated by inactivation of CRTC1/CREB pathway in sensory neurons (conserved in worms)

• Suggested role in metabolism, TRPV1 null mutant mice have protection against diet-induced obesity

Riera (2014), Motter (2008)