• Cyclooxygenase 1/2

• Inflammation

• Key inflammatory enzymes, responsible for conversion of arachidonic acid to precursors of prostaglandin, thromboxane, and prostacyclin. Target for non-steroidal anti-inflammatory drugs (NSAIDs)

• Associated with age-related diseases, lower frequency of pro-inflammatory alleles in centenarians

Naumova (2011)