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Spermidine
Chemical Formula: C7H19N3
Chemical Formula: C7H19N3
Exact Mass: 145.16 g/mol
Exact Mass: 145.16 g/mol
Molecular Weight: 145.25 g/mol
Molecular Weight: 145.25 g/mol
Elemental Analysis: C(57.88%) H(13.19%) N(28.93%)
Elemental Analysis: C(57.88%) H(13.19%) N(28.93%)
SMILES: C(CCNCCCN)CN
SMILES: C(CCNCCCN)CN
PubChem CID: 1102
Chemical Structure:
Alternative Names
Alternative Names
Source
Source
Mushrooms
Aged cheese
Soybeans (natto)
Protein Target/Signalling
Protein Target/Signalling
AMPK
EP300
Biological Pathway
Biological Pathway
mTOR
IGF/IIS
Epigenetic modification
Longevity-Related Effects/Anti-ageing mechanism
Longevity-Related Effects/Anti-ageing mechanism
Lifespan extension in mice
Macrophagy inhibitor, autophagy inducer, HAT inhibitor, somatic cell reprogramming
Biological Activity
Biological Activity
Similar to rapamycin, no immunosuppressive side effects
Regulation of lipid metabolism via AMPK to amerliorate non-alcoholic fatty liver disease in mice
Induces autophagy by competing with acetyl CoA for binding to the catalytic site of EP300
Extension of lifespan and cardioprotective in mice
High intake linked to lower mortality in humans
Reference
Reference
López-Otín (2013), Gao (2018c), Pietrocola (2014), Eisenberg (2016), Kiechl (2018)
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