• Sirtuin 6

• Epigenetic modification

• Regulates genomic stability, NF-κB signalling, and glucose homeostasis through H3K9 deacetylation

• Mice deficient in SIRT6 exhibit accelerated ageing

• Male mice overexpressing Sirt6 have longer lifespan associated with reduced serum IGF-1, higher levels of IGF-binding protein 1, and altered phosphorylation level of major components of IGF-1 signalling

• Can modulate inflammatory response

López-Otín (2013), Mostoslavsky (2006), Kanfi (2012)