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ULK1
Name
Name
Unc-51-like autophagy activating kinase 1
Relevant Pathway
Relevant Pathway
Function
Function
Key upstream initiator of autophagy, directly phosphorylated by AMPK. Part of Atg1 kinase complex for initiation of autophagy. Opposing phosphorylation occurs by mTORC1 when nutrients are plentiful to prevent activation
Role in Longevity
Role in Longevity
Reference
Reference
Hansen (2018), Egan (2011)
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