Embedded Files
SKN-1
Name
Name
Protein skinhead-1
Relevant Pathway
Relevant Pathway
Function
Function
Ortholog of mammalian NRF2
SKN-1A/Nrf1 associates with ER, regulates transcription of proteasome subunit genes to increase proteasome biogenesis when proteasome is inhibited
Role in Longevity
Role in Longevity
Increase in SKN-1A levels extends C. elegans lifespan, preserves cellular function during ageing by limiting accumulation of unfolded and damaged proteins
Reference
Reference
Lehrbach (2019)
Page updated
Google Sites
Report abuse