• 3,4’,5 trihydoxystilbene

• Grapes

• Wine

• SIRT1

• PARP

• PPAR

• Antioxidant signalling

• Epigenetic modification

• Activator of Sirt1, disputed. Improves longevity in respiratory chain complex I mutant C. elegans

• Lifespan extension in HFD-fed mice

• Mitohormesis, somatic cell reprogramming

• Inhibition of cardiac voltage-gated sodium channels

• Cardioprotective

• Antioxidative, anti-inflammatory, and hepatoprotective on oxidative stress-induced liver damage in tilapia

• Protective against oxidative stress through activation of Keap-1/Nrf2 in rats

• Upregulation of tight junction proteins to enhance intestinal barrier function in Caco-2 cells monolayers

• Protection of photoreceptors by blocking caspase and PARP-dependent cell death pathways

• Potential in managing diabetes, cardiovascular and neurological diseases

• Downregulation of endothelin type B receptors in vascular smooth muscle cells via Sirt1/ERK1/2/NF-κB signalling pathways

• In combination with berberine enhances hypolipidaemic effects in high fat diet-induced mice

• Lifepsan extension in high calorie diet mice via increased insulin sensitivity, reduced IGF-1, increased AMPK and PGC-1α activity, increased mitochondrial number, and improved motor function

López-Otín (2013), Chen (2011), Li (2018), Wallace (2006), Santos (2018), Jia (2019), Li (2018c), Mayangsari (2018), Liu (2018), Pannu (2019), Huang (2018a), Zhu (2018), McCormack (2015), Baur (2006), Howitz (2003), Pacholec (2010)