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PPARα
Name
Name
Peroxisome proliferator-activated receptor alpha
Relevant Pathway
Relevant Pathway
Function
Function
Three isoforms: PPARα, PPARβ/δ, and PPARγ able to binding to long-chain polyunsaturated Fas, key mediators of lipid homeostasis
Role in Longevity
Role in Longevity
Modification improves longevity in respiratory chain complex I mutant C. elegans
Diminished expression of PPARα in various tissues during ageing
Reference
Reference
Dato (2016), McCormack (2015), Echeverría (2016)
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