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PI3K
Name
Name
Phosphoinositide 3-kinase
Function
Function
Coupling to Akt, regulation of cell growth through TSC1/2 complex and mTORC signalling. Inactivation of FOXO-dependent transcription in response to insulin. Promotion of lipid synthesis through activation of SREBP1/2 transcription factors
Role in Longevity
Role in Longevity
Downstream of IGF-1 signallling, downregulation of mTOR and S6K, modulation of TRF1 telomeric protein
Reference
Reference
López-Otín (2013), Fruman (2017), Méndez-Pertuz (2017)
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