Quercetin
Chemical Formula: C15H10O7
Exact Mass: 302.04 g/mol
Molecular Weight: 302.23 g/mol
Elemental Analysis: C(59.61%) H(3.33%) O(37.06%)
SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O
PubChem CID: 5280343
Chemical Structure:
Alternative Names
3′,4′,5,7-tetrahydroxyflavone
Source
Fruits
Vegetables
Red wine
Protein Target/Signalling
SIRT1
PGC-1α
COX-2
SOD
TIMP-1
MMP-13
CD38
Biological Pathway
Epigenetic modification
COX
Lipid metabolism
mTOR
Longevity-Related Effects/Anti-ageing mechanism
Lifespan extension in C. elegans
Inhibitor of CD38, resulting in increased levels of intracellular NAD+
AMPK activation, sirtuin activator
Biological Activity
Neuroprotective against radiation-mediated ER stress and inflammatory responses, cardioprotective, inhibition of cardiac voltage-gated sodium channels
Highest binding free energy to calpain in MDS and docking study of compounds from grape seed extract
Enhancement of lysosomal function via mTOR-TFEB pathway
Protective against inflammation and oxidative stress in rabbit knee osteoarthritis
Mild hormetic
Reference
Suchankova (2009), Rauf (2018), Chatterjee (2018), Santos (2018), Wallace (2006), Loke (2008), Kadri (2019), Li (2019a), Wei (2019), Pietsch (2011), Howitz (2003), Escande (2013