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SGK1
Name
Name
Serum/glucocorticoid regulated kinase-1
Relevant Pathway
Relevant Pathway
Function
Function
Implicated in oxidative stress, apoptosis, and DNA damage. Major effector of metabolic regulation downstream of mTORC2. Regulates opening of mPTP
Role in Longevity
Role in Longevity
Regulates autophagy in both C. elegans and mammalian cells
Elevated autophagy shortens lifespan of C. elegans lacking SGK-1 due to increased mitochondrial permeability
Reference
Reference
Garcia-Martinez (2008), Zhou (2019)
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